Book chapter
Cognitive and behavioral changes in Huntington disease before diagnosis
Handbook of Clinical Neurology, pp.69-91
Handbook of Clinical Neurology, Elsevier
01/01/2017
DOI: 10.1016/B978-0-12-801893-4.00006-7
PMID: 28947127
Abstract
Phenotypic manifestations of Huntington disease (HD) can be detected at least 15 years prior to the time when a motor diagnosis is given. Advances in clinical care and future research will require consistent use of HD definitions and HD premanifest (prodromal) stages being used across clinics, sites, and countries. Cognitive and behavioral (psychiatric) changes in HD are summarized and implications for ongoing advancement in our knowledge of prodromal HD are suggested. The earliest detected cognitive changes are observed in the Symbol Digit Modalities Test, Stroop Interference, Stroop Color and Word Test-interference condition, and Trail Making Test. Cognitive changes in the middle and near motor diagnostic stages of prodromal HD involve nearly every cognitive test administered and the greatest changes over time (i.e., slopes) are found in those prodromal HD participants who are nearest to motor diagnosis. Psychiatric changes demonstrate significant worsening over time and remain elevated compared with healthy controls throughout the prodromal disease course. Psychiatric and behavior changes in prodromal HD are much lower than that obtained using cognitive assessment, although the psychiatric and behavioral changes represent symptoms most debilitating to independent capacity and wellness.
Details
- Title: Subtitle
- Cognitive and behavioral changes in Huntington disease before diagnosis
- Creators
- Jane S. Paulsen - University of IowaAmanda C. Miller - University of IowaTerry Hayes - University of IowaEmily Shaw - University of Iowa
- Contributors
- A S Feigin (Editor)K E Anderson (Editor)
- Resource Type
- Book chapter
- Publication Details
- Handbook of Clinical Neurology, pp.69-91
- Publisher
- Elsevier; AMSTERDAM
- Series
- Handbook of Clinical Neurology
- DOI
- 10.1016/B978-0-12-801893-4.00006-7
- PMID
- 28947127
- eISSN
- 2212-4152
- ISSN
- 0072-9752
- Number of pages
- 23
- Grant note
- R01 HG003330 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01 NS054893; R01 NS040068 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383317902771
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