Book chapter
Comparison of 5-Fluoro-2’-Deoxyuridine and 5-Fluorouracil in the Treatment of Murine Colon Cancer; Effects on Thymidylate Synthase
Purine and Pyrimidine Metabolism in Man VIII, pp.109-114
Advances in Experimental Medicine and Biology, Springer US
1995
DOI: 10.1007/978-1-4615-2584-4_25
Abstract
The fluoropyrimidines 5-fluoro-2’-deoxyuridine (FdUrd) and 5-fluorouracil (FUra) are both applied in the treatment of patients with colorectal cancer. These agents exert their action after metabolization to the nucleotide level (Fig. 1). The nucleotides 5-fluorouridine triphosphate (FUTP) and 5-fluoro-2’-deoxyuridine triphosphate (FdUTP) may mediate antiproliferative effects by their incorporation into cellular RNA and DNA, respectively. Anabolism to 5-fluorodeoxyuridine monophosphate (FdUMP) causes an inhibition of the key-enzyme of the pyrimidine de novo synthesis, thymidylate synthase (TS)1, 2. FdUrd’s main mechanism of action is thought to be inhibition of TS3, while the action of FUra is incorporation into RNA and TS inhibition in different magnitudes, depending on the schedule4, 5.
Details
- Title: Subtitle
- Comparison of 5-Fluoro-2’-Deoxyuridine and 5-Fluorouracil in the Treatment of Murine Colon Cancer; Effects on Thymidylate Synthase
- Creators
- Clasina L. van der Wilt - Free University HospitalJan A. M. van Laar - Roswell Park Cancer InstituteKees Smid - Free University HospitalYoucef M. Rustum - Roswell Park Cancer InstituteGodefridus J. Peters - Free University Hospital
- Resource Type
- Book chapter
- Publication Details
- Purine and Pyrimidine Metabolism in Man VIII, pp.109-114
- Publisher
- Springer US; Boston, MA
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4615-2584-4_25
- eISSN
- 2214-8019
- ISSN
- 0065-2598
- Language
- English
- Date published
- 1995
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359699302771
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