Book chapter
Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control
Serotonin and Sleep: Molecular, Functional and Clinical Aspects, pp.529-554
Birkhäuser Basel
2008
DOI: 10.1007/978-3-7643-8561-3_21
Abstract
Serotonergic neurons in the midbrain and medulla are sensitive to changes in serum CO2 concentrations. Medullary serotonergic neurons project to brainstem respiratory control centers and stimulate breathing. Midbrain serotonergic neurons project to thalamocortical circuitry responsible for sleep-wake modulation. There is state-dependent modulation of these medullary serotonergic neurons that may be responsible for state-dependent changes in respiratory rate and breathing regularity. Thus, with projections to both respiratory control centers and thalamocortical arousal circuits, chemosensitive serotonergic neurons are poised to induce both arousal and increased ventilation in response to potentially lifethreatening increases in PCO2. This may have important implications for such clinical conditions as sudden infant death syndrome, obstructive sleep apnea, and panic disorder; disorders in which serotonin is thought to contribute to the underlying pathophysiology.
Details
- Title: Subtitle
- Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control
- Creators
- Gordon F Buchanan - Department of Neurology, Yale University, New HavenMatthew R Hodges - Department of Neurology, Yale University, New HavenGeorge B Richerson - Veteran’s Affairs Medical Center, West Haven
- Resource Type
- Book chapter
- Publication Details
- Serotonin and Sleep: Molecular, Functional and Clinical Aspects, pp.529-554
- DOI
- 10.1007/978-3-7643-8561-3_21
- Publisher
- Birkhäuser Basel; Basel
- Language
- English
- Date published
- 2008
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020873602771
Metrics
17 Record Views