Book chapter
Corneal Wound Healing, Recurrent Corneal Erosions, and Persistent Epithelial Defects
Albert and Jakobiec's Principles and Practice of Ophthalmology, pp.331-360
Springer International Publishing, Fourth edition
04/23/2022
DOI: 10.1007/978-3-030-42634-7_212
Abstract
The process of corneal wound healing involves tightly regulated epithelial proliferation, differentiation, migration, and matrix remodeling. When the corneal epithelium fails to regenerate and adhere to the underlying stroma properly, recurrent corneal erosions (RCEs) and/or persistent epithelial defects (PEDs) may occur. There are many etiologies for RCEs/PEDs, but both are frequently associated with prior trauma or underlying corneal disease. While most acute erosive episodes will resolve with conservative lubrication and/or occlusive techniques such as bandage contact lenses or tarsorrhaphy, adjunctive medical and surgical approaches may be indicated and effective. However, it is often very challenging to manage nonhealing or persistent epithelial defects. As our understanding of the mechanisms of corneal epithelial homeostasis and related tissue reaction to injury continues to advance, our therapeutic regimens will become more targeted toward the underlying mechanisms.
Details
- Title: Subtitle
- Corneal Wound Healing, Recurrent Corneal Erosions, and Persistent Epithelial Defects
- Creators
- Grace L PaleyMichael D WagonerNatalie A AfshariRoberto PinedaAndrew J. W HuangKenneth R KenyonDimitri T AzarMark I Rosenblatt
- Resource Type
- Book chapter
- Publication Details
- Albert and Jakobiec's Principles and Practice of Ophthalmology, pp.331-360
- Edition
- Fourth edition
- Publisher
- Springer International Publishing; Cham
- DOI
- 10.1007/978-3-030-42634-7_212
- Language
- English
- Date published
- 04/23/2022
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984244595302771
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