Book chapter
Crosstalk between brain and the coagulation system
Brain and Organ Communication, pp.229-249
Elsevier Science & Technology
2024
DOI: 10.1016/B978-0-443-22268-9.00013-2
Abstract
Brain coagulation crosstalk signifies bidirectional communication between the central nervous system (CNS) and the coagulation system, regulating blood clot formation. It involves reciprocal influences, challenging the notion of their independence. Research reveals neural regulation where the brain impacts coagulation via pathways like the sympathetic nervous system and stress responses. Conversely, coagulation influences the CNS, affecting neuronal function and the blood–brain barrier. Complex molecular pathways, cellular components, and genetic factors contribute to this crosstalk. Dysregulation links to neurological disorders, strokes, traumatic brain injuries, and psychiatric disorders. Understanding these intricacies holds clinical significance for diagnosis and treatment. Ongoing research seeks to unveil specific mechanisms, identify therapeutic targets, and optimize CNS–coagulation balance. This knowledge may drive personalized interventions and precision medicine, improving patient outcomes by targeting the brain–coagulation interface.
Details
- Title: Subtitle
- Crosstalk between brain and the coagulation system
- Creators
- Massimo LampertiVinay ByrappaMukilan BalasubramanianAmit Jain
- Contributors
- Hemanshu Prabhakar (Editor)Charu Mahajan (Editor)Indu Kapoor (Editor)
- Resource Type
- Book chapter
- Publication Details
- Brain and Organ Communication, pp.229-249
- DOI
- 10.1016/B978-0-443-22268-9.00013-2
- Publisher
- Elsevier Science & Technology; United States
- Language
- English
- Date published
- 2024
- Academic Unit
- Anesthesia
- Record Identifier
- 9984845398702771
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