Cyclooxygenase-2 expression and activity are induced by amyloid-beta 1-42 in brain derived cells

MacKenzie Hilfers Bilunas; Steven A Moore

doi:10.1007/978-1-4615-0193-0_15

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Cyclooxygenase-2 expression and activity are induced by amyloid-beta 1-42 in brain derived cells

Book chapter

Peer reviewed

Cyclooxygenase-2 expression and activity are induced by amyloid-beta 1-42 in brain derived cells

MacKenzie Hilfers Bilunas and Steven A Moore

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5, pp.93-99

Advances in experimental medicine and biology, 507, Springer

2002

DOI: 10.1007/978-1-4615-0193-0_15

PMID: 12664570

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Abstract

One of the early events in Alzheimer’s disease (AD) is the extracellular deposition of amyloid-beta peptide (An), a 39- to 43- amino acid cleavage product of the transmembrane glycoprotein, amyloid precursor protein. Excess A13 within the brain has long been thought to play a major role in AD pathogenesis, however, the mechanisms of its actions are highly debatable. Recent evidence suggests that inflammation may be the pathogenetic link between AP deposition and neuronal death (Halliday et al., 2000).

Amyloid beta-Peptides - pharmacology

Animals

Animals, Newborn

Astrocytes - cytology

Astrocytes - drug effects

Astrocytes - enzymology

Brain - enzymology

Cell Culture Techniques - methods

Cells, Cultured

Cerebrovascular Circulation - drug effects

Cerebrovascular Circulation - physiology

Cyclooxygenase 2

Enzyme Induction - drug effects

Gene Expression Regulation, Enzymologic - drug effects

Isoenzymes - genetics

Mice

Nitric Oxide Synthase - genetics

Nitric Oxide Synthase Type II

Peptide Fragments - pharmacology

Prostaglandin-Endoperoxide Synthases - genetics

Details

Title: Subtitle: Cyclooxygenase-2 expression and activity are induced by amyloid-beta 1-42 in brain derived cells
Creators: MacKenzie Hilfers Bilunas - University of Iowa
Steven A Moore - University of Iowa
Resource Type: Book chapter
Publication Details: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5, pp.93-99
Publisher: Springer; Boston, MA
Series: Advances in experimental medicine and biology; 507
DOI: 10.1007/978-1-4615-0193-0_15
PMID: 12664570
eISBN: 1461501938; 9781461501930
ISSN: 0065-2598
eISSN: 2214-8019
Language: English
Date published: 2002
Academic Unit: Pathology
Record Identifier: 9984186419402771

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