Cystic Fibrosis (CFTR)‐Associated Pancreatic Disease

Chee Y Ooi; Aliye Uc

doi:10.1002/9781119188421.ch47

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Book chapter

Cystic Fibrosis (CFTR)‐Associated Pancreatic Disease

Chee Y Ooi and Aliye Uc

The Pancreas, pp.391-396

John Wiley & Sons, Ltd

03/07/2018

DOI: 10.1002/9781119188421.ch47

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Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) is critical for pancreas health and its deficiency leads to a variety of pancreatic damage from recurrent inflammation to chronic damage, exocrine pancreatic insufficiency, diabetes, and potentially cancer. Although treatment of CFTR‐related pancreatic disease has targeted the sequelae so far, future therapeutics should focus on correcting and/or modulating CFTR function in the pancreas.

acute recurrent pancreatitis

CFTR correctors

CFTR potentiators

chronic pancreatitis

cystic fibrosis

diabetes mellitus

exocrine pancreatic insufficiency

gene therapy

pancreatic enzymes

sweat chloride

Details

Title: Subtitle: Cystic Fibrosis (CFTR)‐Associated Pancreatic Disease
Creators: Chee Y Ooi
Aliye Uc
Contributors: Hans G Beger (Editor)
Andrew L Warshaw (Editor)
Ralph H Hruban (Editor)
Markus W Büchler (Editor)
Markus M Lerch (Editor)
John P Neoptolemos (Editor)
Tooru Shimosegawa (Editor)
David C Whitcomb (Editor)
Christiane Groß (Editor)
Resource Type: Book chapter
Publication Details: The Pancreas, pp.391-396
DOI: 10.1002/9781119188421.ch47
Publisher: John Wiley & Sons, Ltd; Chichester, UK
Number of pages: 6
Language: English
Date published: 03/07/2018
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984314284102771

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