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Descemet’s Membrane Endothelial Keratoplasty (DMEK) - Chapter 16
Book chapter

Descemet’s Membrane Endothelial Keratoplasty (DMEK) - Chapter 16

Shaily Dinesh Shah, Ashley Brissette and Christopher S Sales
Operative Dictations in Ophthalmology, pp.69-76
Springer, Second edition
2021
DOI: 10.1007/978-3-030-53058-7_16

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Abstract

Selective replacement of the corneal endothelium was introduced as a theoretical concept and first performed in humans with graft-retaining sutures in the 1950s by Drs. Jose Barraquer and Charles Tillet. In the late 1990s and early 2000s, deep lamellar endothelial keratoplasty (DLEK), which involved painstaking manual dissection of the recipient and donor followed by a graft-supporting air bubble tamponade, was introduced by Drs. Gerrit Melles and Mark Terry. DLEK evolved into Descemet’s stripping endothelial keratoplasty (DSEK) with introduction of the “descemetorhexis” by Dr. Melles to simplify recipient preparation, and further evolved into descemet stripping automated endothelial keratoplasty (DSAEK) with Dr. Mark Gorovoy’s introduction of the microkeratome to speed donor lenticule preparation. By 2011, DSAEK became the standard of care for endothelial disease and surpassed penetrating keratoplasty as the most commonly performed corneal transplant surgery in the United States.

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