Book chapter
Donor Risk Indices - 11
Transplantation of the Pancreas, pp.159-166
Springer International Publishing, Second Edition
01/01/2023
DOI: 10.1007/978-3-031-20999-4_11
Abstract
Simultaneous pancreas kidney (SPK) transplant has successfully treated patients with type I diabetes mellitus and end-stage renal disease for half a century resulting in euglycemia and normal renal function. However, despite long-term success, there has been a period (2004–2015) of decreasing enthusiasm for pancreas transplant and the average wait time for a SPK transplant in the United States is now 12–19 months. Although donor selection criteria were traditionally limited to mitigate early allograft loss, in response to changing donor demographics, programs now consider allografts from donors who are older, heavier, and have evidence of premortem injury. Similarly, organs procured from donors after cardiac death are being used more often than before. Predictive scoring systems have been developed to objectively assess the risk of early failure, especially when utilizing nontraditional donor organs. There are two established predictive scores/indices that have been validated to identify suitable pancreas donors: The P-PASS in Europe and the PDRI in the United States. The aim of this chapter is to touch on the history of how these scores/indices were formulated, compare them, and evaluate the feasibility of their practical application. We will also briefly touch on studies that include factors not considered in the P-PASS and PDRI scores.
Details
- Title: Subtitle
- Donor Risk Indices - 11
- Creators
- Priyadarshini Manay - University of IowaDavid A Axelrod - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Transplantation of the Pancreas, pp.159-166
- Edition
- Second Edition
- Publisher
- Springer International Publishing; Cham, Switzerland
- DOI
- 10.1007/978-3-031-20999-4_11
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Surgery
- Record Identifier
- 9984503056302771
Metrics
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