Book chapter
Drug Eluting Degradable Coatings on Biomedical Implants
Emerging Technologies in Biophysical Sciences: A World Scientific Reference, pp.407-434
World Scientific
2023
DOI: 10.1142/9789811226090_0014
Abstract
Biomedical implants are widely used in applications ranging from orthopedic and craniofacial to intraocular and cardiovascular. Despite their prevalence, there are still problems. For example, sometimes the implant is treated as a foreign body which can lead to the activation of inflammatory and immune responses, and eventually to implant rejection. Drug-eluting polymeric coatings (DEPCs) are one strategy employed to overcome this. A chosen drug can address the implant associated issues while additionally having an intended therapeutic effect. Depending on the physicochemical characteristics of the chosen combination of polymer and drug, such as chemical structure, degree of crystallinity, glass transition temperature, and drug content, the polymer degradation kinetics and subsequent drug release rate can be varied. However, a proposed DEPC cannot reach clinical relevance unless it meets specific criteria. It must be safe for the consumer, effectively deliver the drug within the therapeutic window, and be cost-effective to manufacture. DEPC formulations are undergoing continued improvements, and there have been encouraging experimental studies and clinical trials demonstrating their potential. On the market today, there are a multitude of degradable coatings on implants making the future of this type of delivery system highly promising.
Details
- Title: Subtitle
- Drug Eluting Degradable Coatings on Biomedical Implants
- Creators
- Juliana C. Quarterman - University of IowaBrittany E. Givens - University of IowaSean M. Geary - University of IowaAliasger K. Salem - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Emerging Technologies in Biophysical Sciences: A World Scientific Reference, pp.407-434
- DOI
- 10.1142/9789811226090_0014
- Publisher
- World Scientific; Singapore
- Language
- English
- Date published
- 2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9984530556502771
Metrics
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