Book chapter
Drug Resistance Mediated by AEG-1/MTDH/LYRIC
Advances in Cancer Research, pp.135-157
Elsevier Science & Technology
2013
DOI: 10.1016/B978-0-12-401676-7.00005-X
PMCID: PMC3967868
PMID: 23889990
Abstract
AEG-1/MTDH/LYRIC has been shown to promote cancer progression and development. Overexpression of AEG-1/MTDH/LYRIC correlates with angiogenesis, metastasis, and chemoresistance to various chemotherapy agents in cancer cells originating from a variety of tissues. In this chapter, we focus on the role of AEG-1/MTDH/LYRIC in drug resistance. Mechanistic studies have shown that AEG-1/MTDH/LYRIC is involved in classical oncogenic pathways including Ha-Ras, myc, NFκB, and PI3K/Akt. AEG-1/MTDH/LYRIC also promotes protective autophagy by activating AMP kinase and autophagy-related gene 5. Another reported mechanism by which AEG-1/MTDH/LYRIC regulates drug resistance is by increasing loading of multidrug resistance gene (MDR) 1 mRNA to the polysome, thereby facilitating MDR1 protein translation. More recently, a novel function for AEG-1/MTDH/LYRIC as an RNA-binding protein was elucidated, which has the potential to impact expression of drug sensitivity or resistance genes. Finally, AEG-1/MTDH/LYRIC acts in microRNA-directed gene silencing via an interaction with staphylococcal nuclease and tudor domain containing 1, a component of the RNA-induced silencing complex. Altered microRNA expression and activity induced by AEG-1/MTDH/LYRIC represent an additional way that AEG-1/MTDH/LYRIC may cause drug resistance in cancer. The multiple functions of AEG-1/MTDH/LYRIC in drug resistance highlight that it is a viable target as an anticancer agent for a wide variety of cancers.
Details
- Title: Subtitle
- Drug Resistance Mediated by AEG-1/MTDH/LYRIC
- Creators
- Xiangbing Meng - Department of Obstetrics and Gynecology, The University of Iowa, Iowa City, Iowa, USAKristina W Thiel - Department of Obstetrics and Gynecology, The University of Iowa, Iowa City, Iowa, USAKimberly K Leslie - Department of Obstetrics and Gynecology, The University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Book chapter
- Publication Details
- Advances in Cancer Research, pp.135-157
- DOI
- 10.1016/B978-0-12-401676-7.00005-X
- PMID
- 23889990
- PMCID
- PMC3967868
- NLM abbreviation
- Adv Cancer Res
- eISSN
- 2162-5557
- ISSN
- 0065-230X
- Publisher
- Elsevier Science & Technology
- Language
- English
- Date published
- 2013
- Academic Unit
- Pathology; Obstetrics and Gynecology
- Record Identifier
- 9983931741402771
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