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Dynamic Assemblies in Genome Maintenance
Book chapter   Peer reviewed

Dynamic Assemblies in Genome Maintenance

Paras Gaur and Maria Spies
Supramolecular Protein Assemblies In Cells, pp.113-156
Advances in experimental medicine and biology, v. 1514, Springer
2026
DOI: 10.1007/978-3-032-26629-3_6
PMID: 42334540

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Abstract

The integrity of the human genome is continuously challenged by diverse endogenous and exogenous threats that damage DNA and disrupt its replication. When the replication machinery encounters such obstacles, including lesions or non-canonical DNA structures, it may stall, initiate repair, or activate specialized pathways to bypass the impediment. Maintaining replication progression requires a coordinated and dynamic assembly of numerous nucleoprotein complexes that recognize, process, and resolve DNA damage and replication stalling structures. This chapter highlights how proliferating cell nuclear antigen (PCNA), poly(ADP-ribose) polymerase 1 (PARP1), and non-canonical DNA structures are integrated into higher-order supramolecular complexes that stabilize, remodel, or resolve stalled or damaged replication forks. The molecular events carried out by these supramolecular complexes are essential for preserving genomic integrity in human cells. Moreover, many of the factors involved emerge as attractive therapeutic targets for diseases driven by genome instability, including cancer.
 DNA Repair DNA Replication Animals DNA - chemistry DNA - genetics DNA - metabolism DNA Damage Genome, Human Genomic Instability Humans Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism

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