Book chapter
Effects of CpG DNA on Th1/Th2 balance in asthma
Immunobiology of Bacterial CpG-DNA, pp.211-225
Current topics in microbiology and immunology, 247, Springer-Verlag
2000
DOI: 10.1007/978-3-642-59672-8_15
PMID: 10689790
Abstract
Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also effective in down-regulation of established Th2 responses. This protection is neither murine strain-dependent nor model-dependent. Although these effects of CpG ODN are associated with the induction of the Th1 cytokines IFN-gamma and IL-12, neither cytokine is absolutely required for the protection. These results suggest that CpG ODN may be an effective immunomodulatory agent in the treatment, and possibly prevention, of asthma.
Details
- Title: Subtitle
- Effects of CpG DNA on Th1/Th2 balance in asthma
- Creators
- J N Kline - Division of Pulmonary Medicine, University of Iowa College of Medicine, Iowa City 52242, USA. joel-kline@uiowa.edu
- Resource Type
- Book chapter
- Publication Details
- Immunobiology of Bacterial CpG-DNA, pp.211-225
- Publisher
- Springer-Verlag
- Series
- Current topics in microbiology and immunology; 247
- DOI
- 10.1007/978-3-642-59672-8_15
- PMID
- 10689790
- ISSN
- 0070-217X
- Language
- English
- Date published
- 2000
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094640002771
Metrics
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