Book chapter
Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein
Cancer Sensitizing Agents for Chemotherapy, pp.67-96
Elsevier
01/01/2020
DOI: 10.1016/B978-0-12-816434-1.00003-6
Abstract
Breast cancer resistance protein (BCRP, ABCG2) is one of the major ATP binding cassette (ABC) transporter proteins involved in multi-drug resistance of cancer therapy. In the past two decades, BCRP has been extensively studied and substantial knowledge on BCRP has been gained in terms of its structure, function, expression, as well as its role in drug resistance and drug transport. BCRP is expressed in various types of human cancers and it recognizes and transports numerous anticancer drugs, including conventional chemotherapeutics, molecular targeted anticancer agents, and photodynamic therapy (PDT) agents. Significant effort has been devoted to develop treatment strategies to overcome BCRP-mediated resistance. In addition, BCRP is expressed in many normal tissues and plays an important role in drug absorption, distribution, and elimination. This book chapter summarizes current knowledge on this medically important efflux transporter obtained from studies at the molecular, tissue, and system levels, with a focus on its relevance in cancer resistance and drug transport.
Details
- Title: Subtitle
- Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein
- Creators
- Guohua An - University of IowaMarilyn E. Morris - State University of New York
- Contributors
- A Sosnik (Editor)R Bendayan (Editor)
- Resource Type
- Book chapter
- Publication Details
- Cancer Sensitizing Agents for Chemotherapy, pp.67-96
- Publisher
- Elsevier; LONDON
- DOI
- 10.1016/B978-0-12-816434-1.00003-6
- eISSN
- 2468-3116
- ISSN
- 2468-3183
- Number of pages
- 30
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984366401602771
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