Book chapter
Engineering Organoid Systems to Model Health and Disease
Cell Therapy, pp.197-226
Molecular and Translational Medicine, Springer International Publishing
08/26/2017
DOI: 10.1007/978-3-319-57153-9_10
Abstract
Much of the in vitro study of organs relies on responses from monolayers composed of one or more cell types; however, in many cases, this simplistic modeling of the organ system does not replicate how cells behave in vivo in the context of their organ and organism. While many useful cell characteristics can be deduced from 2D cell cultures, a full understanding of organ systems and biology requires studying cells in the context of their native environment. Traditionally, animal models have fulfilled this role; however, in the past decade, techniques and technologies to grow 3D tissue organoids in culture have been developed as an intermediate or replacement for in vivo studies. In this chapter, we review the genesis of organoid culture systems and provide an in-depth view of several fields that have been significantly impacted by organoid technology. Finally, we summarize emerging applications of organoids in modeling health and disease, treating patients, and discovering novel pharmaceuticals.
Details
- Title: Subtitle
- Engineering Organoid Systems to Model Health and Disease
- Creators
- James A Ankrum - Department of Biomedical Engineering, FOE Diabetes Research Center, University of Iowa Hospitals and Clinics, Iowa City, USAThomas J Bartosh - Department of Medical Physiology, Texas A&M University Health Science Center, Temple, USAXiaolei Yin - Department of Medicine, Brigham and Women’s Hospital, Boston, USAAlexander J Brown - Department of Biomedical Engineering, FOE Diabetes Research Center, University of Iowa Hospitals and Clinics, Iowa City, USAAnthony J Burand - Department of Biomedical Engineering, Iowa City, USALauren Boland - Department of Biomedical Engineering, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Cell Therapy, pp.197-226
- Publisher
- Springer International Publishing; Cham
- Series
- Molecular and Translational Medicine
- DOI
- 10.1007/978-3-319-57153-9_10
- eISSN
- 2197-7860
- ISSN
- 2197-7852
- Language
- English
- Date published
- 08/26/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984001089002771
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