Book chapter
Epidemiology, etiology, and genetics of orofacial clefting
Cleft and Craniofacial Orthodontics, pp.39-60
John Wiley & Sons, Inc
03/10/2023
DOI: 10.1002/9781119778387.ch4
Abstract
This chapter reviews the epidemiology, etiology, and genetic risk factors for syndromic and non‐syndromic orofacial clefting (OFC), as well as genetic counseling for affected families. Maternal smoking during pregnancy is the most replicated risk factor for OFC. OFCs show strong familial aggregation, which suggests a strong genetic component to their etiology. Features of OFC have been recognized in over 460 conditions with known molecular basis. The chapter summarizes the main clinical characteristics, genetic etiology, and biological mechanisms underlying cleft syndromes most often seen in a clinical setting. Van der Woude syndrome is an autosomal dominant condition that affects 1/35,000 individuals and accounts for 2% of orofacial clefts. Different types of genetic studies allow researchers to map genes in the absence of a well‐defined model of inheritance. There are two general types of statistical approaches – “linkage analysis” and “association analysis.”
Details
- Title: Subtitle
- Epidemiology, etiology, and genetics of orofacial clefting
- Creators
- Lina M. Moreno UribeMary L Marazita
- Contributors
- Pradip R Shetye (Editor)Travis L Gibson (Editor)
- Resource Type
- Book chapter
- Publication Details
- Cleft and Craniofacial Orthodontics, pp.39-60
- DOI
- 10.1002/9781119778387.ch4
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ, USA
- Number of pages
- 22
- Language
- English
- Date published
- 03/10/2023
- Academic Unit
- Orthodontics; Craniofacial Anomalies Research Center
- Record Identifier
- 9984367680002771
Metrics
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