Book chapter
Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Handbook of Stem Cell Applications, pp.739-762
Springer Nature Singapore
01/01/2024
DOI: 10.1007/978-981-99-7119-0_30
Abstract
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in the conducting airways can be due to environmental insults or disease-induced tissue remodeling. Therefore, rapid epithelial regeneration following acute lung injury is critical for reestablishing airway barrier function and mucociliary clearance, preventing further damage. The ability of airway stem cell(s) to replace injured or defective cells, however, is not fully understood and this limits our understanding of end-stage lung diseases preventing the development of therapeutic tools to halt the progression from acute injury to end-stage disease. In this chapter, we discuss known SC niches in lung epithelium, their regenerative capabilities, the impact of chronic disease on injury response, and epithelial reconstitution. In addition, we will highlight current in vivo and in vitro models of airway injury and discuss the potential role of stem cell therapy. These processes are important for the maintenance and regenerative capacity of airway epithelia. A better understanding of the airway stem cell biology in homeostatic conditions and chronic injury states will help bridge the knowledge gap necessary to overcome stem cell therapies’ challenges to treat or prevent end-stage lung disease.
Details
- Title: Subtitle
- Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
- Creators
- Kyle FreischlagVitaly IevlevKalpaj R. ParekhKhawaja Husnain HaiderSimon D. Tran
- Resource Type
- Book chapter
- Publication Details
- Handbook of Stem Cell Applications, pp.739-762
- Publisher
- Springer Nature Singapore; Singapore
- DOI
- 10.1007/978-981-99-7119-0_30
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Anatomy and Cell Biology; Cardiothoracic Surgery
- Record Identifier
- 9984580297602771
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