Book chapter
Epstein–Barr Virus (EBV)
Encyclopedia of the Neurological Sciences, pp.201-205
Elsevier Inc, Second Edition
2014
DOI: 10.1016/B978-0-12-385157-4.00377-8
Abstract
Epstein–Barr virus (EBV) is a well-known cause of neurological disease. The most recognized form of EBV infection is infectious mononucleosis (IM), the primary EBV infection that occurs in adolescents and young adults. Neurological complications are seen in 1–5% of children with IM, which include meningoencephalitis, transverse myelitis, Guillain–Barré syndrome, cranial neuropathy, and acute psychosis. Generally the neurological complications associated with acute EBV infection resolve without permanent sequelae. Recently, a more ominous association has been recognized between symptomatic IM in adolescence and subsequent development of multiple sclerosis (MS) in later adulthood. As EBV deoxyribonucleic acid (DNA) is not found in the cerebrospinal fluid (CSF) of MS patients, EBV infection does not lead directly to MS. Instead, symptomatic IM appears to identify a subpopulation at risk for subsequent development of MS.
The current methods for diagnosis of EBV infection as well as the current management of EBV-related neurological disease are also discussed.
Details
- Title: Subtitle
- Epstein–Barr Virus (EBV)
- Creators
- C. Grose - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Encyclopedia of the Neurological Sciences, pp.201-205
- Edition
- Second Edition
- Publisher
- Elsevier Inc
- DOI
- 10.1016/B978-0-12-385157-4.00377-8
- Language
- English
- Date published
- 2014
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984354041602771
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