Book chapter
Equine Infectious Anaemia Virus Pathogenesis and Replication
Lentiviruses and macrophages : molecular and cellular interactions, pp.251-275
Caister Academic Press
2010
Abstract
Equine infectious anaemia virus (EIAV) is an ungulate lentivirus related to human immunodeficiency virus (HIV). Much of the understanding of lentiviral infection of macrophages comes from HIV studies that have provided insights into molecular regulation of all lentiviruses. However, numerous aspects of the life cycle of each lentivirus are unique and associated with specific pathological consequences. In vivo EIAV is primarily if not exclusively a macrophage-tropic virus. As a consequence of this targeted tropism, ELAV causes an acute and sometimes fulminant disease associated with high-titred viraemia with no associated immunodeficiency. Investigations have only begun to unravel the molecular mechanisms leading to cell-specific replication of EIAV. This chapter provides an overview of the molecular biology of ELAV replication and the pathogenesis associated with infection of macrophages.
Details
- Title: Subtitle
- Equine Infectious Anaemia Virus Pathogenesis and Replication
- Creators
- Wendy Maury - Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USAJ. Lindsay Oaks - Washington State Univ, Coll Vet Med, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA
- Contributors
- Moira Desport (Editor)
- Resource Type
- Book chapter
- Publication Details
- Lentiviruses and macrophages : molecular and cellular interactions, pp.251-275
- Publisher
- Caister Academic Press; Norfolk, UK
- Number of pages
- 25
- Language
- English
- Date published
- 2010
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297533302771
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