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Fabrication and Applications of Paper-Based Microfluidics
Book chapter

Fabrication and Applications of Paper-Based Microfluidics

Xuan Mu and Yu Shrike Zhang
Diagnostic Devices with Microfluidics, pp.45-64
CRC Press, 1
2017
DOI: 10.1201/9781315154442-3

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Abstract

Microfabrication in paper-based microfluidics relies on the engineering techniques to pattern paper with hydrophobic areas, which are crucial features and prerequisites to achieve sophisticated analytical functions on paper. This chapter describes newly developed fabrication methods, and the choice of fabrication methods depends on specific contexts and paper used. It focuses on the applications that are of the most clinical relevance, presenting the bottlenecks in current clinical diagnosis. The photolithography-based fabrication proves the concept and the value of paper-based microfluidics. Inkjet printer, a common office instrument, is applicable to manufacturing paper-based microfluidics. ELISA in the form of plastic well plate is one of the most ubiquitous assays performed in routine clinical laboratories. Blood typing is of great clinical significance in blood transfusion and transplantation. Sickle cell disease is a common recessively inherited blood disorder. The accurate and rapid detection of blood groups is imperative to prevent hemolytic transfusion reactions and other fatal consequences.
 Microfluidic Techniques Routine Clinical Laboratories Wax Printing Mechanical Cutting Influenza H1N1 Silicon Dioxide Beads Centralized Medical Centers Resource Limited Settings Fiber Network Sickle Cell Disease Agglutinated Red Blood Cells Biomedical Research Dried Blood Spotting Patterned Paper Hydrophobic Materials Blood Typing Rolling Circle Amplification Sickle Hemoglobin Dengue Virus Urine Dipstick Tests Inkjet Printing Paper Substrate Vascular Endothelial Growth Factor Clinical Diagnostic Tests Clinical Diagnosis

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