Book chapter
Familial Mediterranean Fever and Other Autoinflammatory Disorders
Genetic Disorders Among Arab Populations, pp.111-143
Springer Berlin Heidelberg
04/19/2010
DOI: 10.1007/978-3-642-05080-0_5
Abstract
Autoinflammatory diseases are a group of disorders characterized by seemingly unprovoked inflammation in the absence of high-titer autoantibodies or antigen-specific T-cells (Stojanov and Kastner 2005). The autoinflammatory diseases include the hereditary periodic fever syndromes and are thought to be due to disturbances in the regulation of the innate immunity (Kastner 2005). Familial Mediterranean Fever (FMF) is the archetypal hereditary periodic fever syndrome and autoinflammatory disease. Other disorders include tumor necrosis factor receptor-associated periodic syndrome (TRAPS); hyperimmunoglobulinemia D with periodic fever syndrome (Hyper-IgD); pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome; the cryopyrinopathies: familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also called chronic infantile neurologic cutaneous and articular syndrome, or CINCA syndrome); and chronic recurrent multifocal osteomyelitis (McGonagle and McDermott 2006; Milhavet et al. 2008).
Details
- Title: Subtitle
- Familial Mediterranean Fever and Other Autoinflammatory Disorders
- Creators
- Hatem El-Shanti - Medical Genetics CenterHasan Abdel Majeed - University of Jordan
- Resource Type
- Book chapter
- Publication Details
- Genetic Disorders Among Arab Populations, pp.111-143
- Publisher
- Springer Berlin Heidelberg; Berlin, Heidelberg
- DOI
- 10.1007/978-3-642-05080-0_5
- Language
- English
- Date published
- 04/19/2010
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984354057402771
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