Book chapter
Ferret respiratory disease models for the study of lung stem cells
Lung Stem Cells in Development, Health and Disease Lung Stem Cells in Development, Health and Disease, Vol.2021(91), pp.273-289
European respiratory monograph, v. 91, European respiratory Society
2021
DOI: 10.1183/2312508X.10010320
Abstract
Ferrets (Mustela putorius furo) have had an extensive history in modelling respiratory diseases since the 1930s. Ferret and human lungs share conserved anatomical features and cellular compartments that differ from those of rodents. However, it is not yet known whether differences in stem cells or other aspects of anatomy explain why ferrets more accurately model certain airway diseases. In the same way that tissue structure is essential for proper function, tissue remodelling is intricately linked to pathogenesis. Thus, stem cells are vital to maintaining functional architecture and cellular composition. Recent advances in ferret genetic engineering have enabled stem cell fate-mapping, conditional genetics and the creation of disease models that parallel human pathology. Given their docile nature, short 42-day gestation and sexual maturation times (5–6 months), 10-year lifespan, tractability for longitudinal bronchoscopy and pulmonary function testing, and available genome, ferret models have expanded the opportunities to study stem cells in diseases such as CF, COPD, asthma and chronic allograft failure in lung transplantation.
Details
- Title: Subtitle
- Ferret respiratory disease models for the study of lung stem cells
- Creators
- Albert C. Pai - University of IowaKalpaj R. Parekh - University of IowaJohn F. Engelhardt - Dept of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, United StatesThomas J. Lynch - Dept of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, United States
- Resource Type
- Book chapter
- Publication Details
- Lung Stem Cells in Development, Health and Disease Lung Stem Cells in Development, Health and Disease, Vol.2021(91), pp.273-289
- Series
- European respiratory monograph; v. 91
- DOI
- 10.1183/2312508X.10010320
- ISSN
- 2312-508X
- eISSN
- 2312-5098
- Publisher
- European respiratory Society; Sheffield, UK
- Language
- English
- Date published
- 2021
- Academic Unit
- Anatomy and Cell Biology; Cardiothoracic Surgery
- Record Identifier
- 9984949188202771
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