Book chapter
Functional and Anatomical Dissection of Feeding Circuits
Neuroendocrinology of Appetite, pp.112-133
John Wiley & Sons, Ltd
09/21/2016
DOI: 10.1002/9781118839317.ch6
Abstract
This chapter reviews the application of new genetically encoded tools in feeding circuits that regulate appetite. Rapid activation and inhibition of agouti related peptide (AgRP) neurons conclusively established a causal role for rapid control of food intake. Chemogenetic activation of AgRP neurons using hM3Dq avoids the invasive protocols required for ChR2 activation. ChR2 distributes into axons, and selective optogenetic activation of AgRP neuron axon projection fields in distinct brain areas was used to examine their individual contribution to feeding behavior. Some of the brain areas targeted by AgRP neuron axon projections have been examined further for cell type specific control of appetite. Rodents with bed nucleus of stria terminalis (BNST) lesions show hyperphagia and obesity, indicating that reduced BNST output promotes feeding. pro‐opiomelanocortin (POMC) neurons regulate feeding over longer timescales. parabrachial nucleus (PBN) neurons have a powerful inhibitory role on food intake, but their inhibition does not strongly elevate food intake.
Details
- Title: Subtitle
- Functional and Anatomical Dissection of Feeding Circuits
- Creators
- Deniz AtasoyScott M Sternson
- Contributors
- Suzanne L Dickson (Editor)Julian G Mercer (Editor)
- Resource Type
- Book chapter
- Publication Details
- Neuroendocrinology of Appetite, pp.112-133
- DOI
- 10.1002/9781118839317.ch6
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 22
- Language
- English
- Date published
- 09/21/2016
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984065880502771
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