Book chapter
G-Protein–Effector Coupling in the Vertebrate Phototransduction Cascade
G Protein Signaling Mechanisms in the Retina, pp.49-64
Springer Series in Vision Research, Springer New York
09/05/2014
DOI: 10.1007/978-1-4939-1218-6_4
Abstract
For many years, the rod phototransduction cascade has served as a valuable model to study the mechanisms of cellular signaling by G-protein-coupled receptors (GPCRs). Our understanding of the key steps of signal transfer from GPCRs to G proteins and further downstream to G protein effectors has been greatly advanced through extensive biochemical studies in rod photoreceptors. This review focuses on the coupling of the visual G protein transducin to its classical effector phosphodiesterase 6. A new level of mechanistic insight has been achieved from the atomic structures of the signaling molecules. Recent studies on light-dependent translocation of transducin in rods raise a possibility for noncanonical transducin signaling and partners in the photoreceptor synaptic terminal.
Details
- Title: Subtitle
- G-Protein–Effector Coupling in the Vertebrate Phototransduction Cascade
- Creators
- Nikolai O Artemyev - Department of Molecular Physiology and Biophysics, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- G Protein Signaling Mechanisms in the Retina, pp.49-64
- Series
- Springer Series in Vision Research
- DOI
- 10.1007/978-1-4939-1218-6_4
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 09/05/2014
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070987502771
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