Book chapter
Genetic Models of Parkinson's Disease and Their Study in Nonhuman Primates
Conn's Handbook of Models for Human Aging, pp.641-646
Elsevier/Academic Press, Second edition
2018
DOI: 10.1016/B978-0-12-811353-0.00047-6
Abstract
Neurotoxin-based models of Parkinson's disease (PD) have been frequently used for testing antiparkinsonian therapies in nonhuman primates (NHPs). Yet, such models have limitations for mimicking the complexity of the PD syndrome and mechanisms of neurodegeneration found in human PD. Several genetic traits have been linked to sporadic and familial PD cases. Mutations in the α-synuclein (α-syn) gene (SNCA) were the first to be identified in familial PD cases and led to the identification of α-syn as the main component of the Lewy bodies (LBs), a hallmark PD pathology. Since then, different approaches has been studied to model genetic-linked PD in NHPs. Viral vectors encoding for α-syn wild type or mutated have been injected into the brain to recreate regional PD pathology or into fertilized oocytes to induce transgenesis. More recently, inoculations of α-syn or LBs have been attempted. In this chapter we review these models, the current limitations in their characterization and validation, and reflect on the challenges that PD NHP research faces to continue to provide meaningful contributions to the field.
Details
- Title: Subtitle
- Genetic Models of Parkinson's Disease and Their Study in Nonhuman Primates
- Creators
- Corinne A. Jones - University of Wisconsin–MadisonJeanette M. Metzger - University of Wisconsin–MadisonMarina E. Emborg - University of Wisconsin–Madison
- Contributors
- Jeffrey L Ram (Editor)P Michael Conn (Editor)
- Resource Type
- Book chapter
- Publication Details
- Conn's Handbook of Models for Human Aging, pp.641-646
- Edition
- Second edition
- DOI
- 10.1016/B978-0-12-811353-0.00047-6
- Publisher
- Elsevier/Academic Press; London
- Number of pages
- 6
- Language
- English
- Date published
- 2018
- Academic Unit
- Communication Sciences and Disorders
- Record Identifier
- 9985217033002771
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