Book chapter
Genetic and Epigenetic Susceptibility of Peri-Implantitis
Unfolding Peri-implantitis: Diagnosis, Prevention
2022
Abstract
Peri-implantitis is a destructive disease of implant-supporting tissues induced by bacterial biofilm, which provokes an inflammatory host response, influenced by environmental, genetic, and epigenetic factors. Genetics is the science that deals with genes, heredity, and the variations that occur in our genes and DNA, while epigenetics refers to alterations in the gene expression that are not encoded in the DNA sequence, which result in the remodeling of the chromatin and activation or inactivation of a gene. There are three major epigenetic mechanisms: DNA methylation, histone modifications, and microRNAs. The relationship between genetics, epigenetics, and peri-implantitis has been the subject of interest in the recent years; therefore, we aim in this chapter to present the state of the art on the role of genetic and epigenetic mechanisms in peri-implantitis.
Details
- Title: Subtitle
- Genetic and Epigenetic Susceptibility of Peri-Implantitis
- Creators
- Farah Asa'ad - Institute of Clinical Sciences, Department of BiomaterialsCarlos Garaicoa-PazmiñoLena Larsson - Institute of Odontology
- Resource Type
- Book chapter
- Publication Details
- Unfolding Peri-implantitis: Diagnosis, Prevention
- Language
- English
- Date published
- 2022
- Academic Unit
- Periodontics
- Record Identifier
- 9984367599002771
Metrics
31 Record Views