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Hemispheric Refractory Epilepsy
Book chapter

Hemispheric Refractory Epilepsy

Brian J Dlouhy and Matthew D Smyth
Pediatric Neurosurgery
Neurosurgery by Example, Oxford University Press
01/01/2019
DOI: 10.1093/med/9780190617073.003.0015

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Abstract

Medically refractory epilepsy occurs when a patient has failed to become seizurefree on 2 antiepileptic medications. Hemispheric epilepsy is diagnosed with multifocal seizure onset occurring in the same cerebral hemisphere. Video EEG, along with imaging studies such as MRI, SPECT, PET, and MEG, may be helpful for further evaluating the seizure semiology and hemispheric physiology. A hemispherectomy or hemispherotomy can be considered if the remaining hemisphere is normal. The individual anatomy of the patient will determine variations on a hemispherotomy, and the falx and anterior cerebral arteries can be used as key landmarks. Hydrocephalus can be an early or late complication, and careful longterm postoperative followup should be established.

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