Book chapter
Herpesvirus Nuclear Egress
Cell Biology of Herpes Viruses, pp.143-169
Advances in Anatomy, Embryology and Cell Biology, Springer International Publishing
05/21/2017
DOI: 10.1007/978-3-319-53168-7_7
PMID: 28528443
Abstract
Herpesviruses assemble and package their genomes into capsids in the nucleus, but complete final assembly of the mature virion in the cell cytoplasm. This requires passage of the genome-containing capsid across the double-membrane nuclear envelope. Herpesviruses have evolved a mechanism that relies on a pair of conserved viral gene products to shuttle the capsids from the nucleus to the cytoplasm by way of envelopment and de-envelopment at the inner and outer nuclear membranes, respectively. This complex process requires orchestration of the activities of viral and cellular factors to alter the architecture of the nuclear membrane, select capsids at the appropriate stage for egress, and accomplish efficient membrane budding and fusion events. The last few years have seen major advances in our understanding of the membrane budding mechanism and helped clarify the roles of viral and cellular proteins in the other, more mysterious steps. Here, we summarize and place into context this recent research and, hopefully, clarify both the major advances and major gaps in our understanding.
Details
- Title: Subtitle
- Herpesvirus Nuclear Egress
- Creators
- Richard J Roller - Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USAJoel D Baines - Kenneth F. Burns Chair in Veterinary Medicine, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, USA
- Resource Type
- Book chapter
- Publication Details
- Cell Biology of Herpes Viruses, pp.143-169
- Publisher
- Springer International Publishing; Cham
- Series
- Advances in Anatomy, Embryology and Cell Biology
- DOI
- 10.1007/978-3-319-53168-7_7
- PMID
- 28528443
- eISSN
- 2192-7065
- ISSN
- 0301-5556
- Language
- English
- Date published
- 05/21/2017
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001135502771
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