Book chapter
Heterogeneity of Pulmonary Stem Cells
Advances in experimental medicine and biology, pp.95-117
Advances in Experimental Medicine and Biology, Springer Nature
01/01/2019
DOI: 10.1007/978-3-030-24108-7_6
PMCID: PMC8421072
PMID: 31487021
Abstract
Epithelial stem cells reside within multiple regions of the lung where they renew various region-specific cells. In addition, there are multiple routes of regeneration after injury through built-in heterogeneity within stem cell populations and through a capacity for cellular plasticity among differentiated cells. These processes are important facets of respiratory tissue resiliency and organism survival. However, this regenerative capacity is not limitless, and repetitive or chronic injuries, environmental stresses, or underlying factors of disease may ultimately lead to or contribute to tissue remodeling and end-stage lung disease. This chapter will review stem cell heterogeneity among pulmonary epithelia in the lower respiratory system, discuss recent findings that may challenge long-held scientific paradigms, and identify several clinically relevant research opportunities for regenerative medicine.
Details
- Title: Subtitle
- Heterogeneity of Pulmonary Stem Cells
- Creators
- Thomas J. Lynch - Roy J. and Lucille A. Carver College of MedicineVitaly Ievlev - Roy J. and Lucille A. Carver College of MedicineKalpaj R. Parekh - Roy J. and Lucille A. Carver College of Medicine
- Contributors
- A Birbrair (Editor)
- Resource Type
- Book chapter
- Publication Details
- Advances in experimental medicine and biology, pp.95-117
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-3-030-24108-7_6
- PMID
- 31487021
- PMCID
- PMC8421072
- NLM abbreviation
- Adv Exp Med Biol
- eISSN
- 2214-8019
- ISSN
- 0065-2598
- Publisher
- Springer Nature; CHAM
- Number of pages
- 23
- Grant note
- R01HL136370 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30DK054759 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Anatomy and Cell Biology; Cardiothoracic Surgery
- Record Identifier
- 9984284341902771
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