Book chapter
Human Genetics of Atrial Septal Defect: Clinical Features, Human Genetics and Molecular Pathways
Congenital Heart Diseases: The Broken Heart, pp.279-290
Springer Nature
01/01/2016
DOI: 10.1007/978-3-7091-1883-2_20
Abstract
Atrial septal defects and other interatrial communications share the physiologic phenotype of shunting blood from the left to the right atrium, but their genetics and development have important differences. Secundum ASDs are the most common and usually the type implied by clinicians when not otherwise specified. The distinction is important because the development and genetics of ostium primum ASDs, the second most common type, are related to atrioventricular septal defects. Sinus venosus and coronary sinus defects are rare. Their anatomy and development are more properly considered as an interatrial communication rather than a true septal defect. Little is known about their genetics. This chapter focuses on the human genetics of secundum ASD and sinus venosus and coronary sinus defects.
Details
- Title: Subtitle
- Human Genetics of Atrial Septal Defect: Clinical Features, Human Genetics and Molecular Pathways
- Creators
- Rabia Khan - Washington University in St. Louis School of MedicinePatrick Y. Jay - Washington University in St. Louis School of Medicine
- Contributors
- S Rickert-Sperling (Editor)R G Kelly (Editor)D J Driscoll (Editor)
- Resource Type
- Book chapter
- Publication Details
- Congenital Heart Diseases: The Broken Heart, pp.279-290
- Publisher
- Springer Nature; VIENNA
- DOI
- 10.1007/978-3-7091-1883-2_20
- Number of pages
- 12
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Stead Family Department of Pediatrics; Cardiology
- Record Identifier
- 9984354044002771
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