Book chapter
Hypofractionation for Lung Tumors (Primary Malignant, Secondary Malignant)
Hypofractionated and Stereotactic Radiation Therapy, pp.207-234
Springer International Publishing
08/01/2018
DOI: 10.1007/978-3-319-92802-9_18
Abstract
Surgery has traditionally been the standard of care for early-stage (T1–T2 N0) NSCLC and lung metastases as local control with conventionally fractionated EBRT was clearly inferior to surgical resection. However, the emergence of SBRT (1–5 fractions of >5 Gy/fx) for lung lesions is challenging this standard as local control rates of >80–95% can be achieved with either modality. Less extreme hypofractionation (15–25 fractions of 2.5–3.5 Gy/fx) regimens have also been utilized in an attempt to escalate the BED of radiation for more advanced (stages III–IV) NSCLC. Clinical experience has demonstrated that while these approaches can produce encouraging tumor control rates, they are not without the risk of severe, even fatal complications as a result of damage to the many critical structures located in the thorax. This chapter will review the sizeable literature for lung SBRT and hypofractionation regimens and highlight the technical considerations that are necessary to properly utilize these techniques.
Details
- Title: Subtitle
- Hypofractionation for Lung Tumors (Primary Malignant, Secondary Malignant)
- Creators
- Joseph M. Caster - University of IowaAchilles J. Fakiris - Rex HospitalMichael V. Lawrence - University of North Carolina HospitalsEric C. Scheriber - University of North Carolina HospitalsLawrence B. Marks - University of North Carolina Hospitals
- Resource Type
- Book chapter
- Publication Details
- Hypofractionated and Stereotactic Radiation Therapy, pp.207-234
- DOI
- 10.1007/978-3-319-92802-9_18
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 08/01/2018
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984314285502771
Metrics
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