Book chapter
Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling
Precision Approaches to Heterogeneity in Asthma , pp.163-184
Advances in experimental medicine and biology, v. 1426
01/01/2023
DOI: 10.1007/978-3-031-32259-4_8
PMCID: PMC13401788
PMID: 37464121
Abstract
The imaging of asthma using chest computed tomography (CT) is well-established (Jarjour et al., Am J Respir Crit Care Med 185(4):356–62, 2012; Castro et al., J Allergy Clin Immunol 128:467–78, 2011). Moreover, recent advances in functional imaging of the lungs with advanced computer analysis of both CT and magnetic resonance images (MRI) of the lungs have begun to play a role in quantifying regional obstruction. Specifically, quantitative measurements of the airways for bronchial wall thickening, luminal narrowing and distortion, the amount of mucus plugging, parenchymal density, and ventilation defects that could contribute to the patient’s disease course are instructive for the entire care team. In this chapter, we will review common imaging methods and findings that relate to the heterogeneity of asthma. This information can help to guide treatment decisions. We will discuss mucous plugging, quantitative assessment of bronchial wall thickening, delta lumen phenomenon, parenchymal low-density lung on CT, and ventilation defect percentage on MRI as metrics for assessing regional ventilatory dysfunction.
Details
- Title: Subtitle
- Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling
- Creators
- Mark L SchieblerNanae TsuchiyaAndrew HahnSean FainLoren DenlingerNizar JarjourEric A Hoffman
- Resource Type
- Book chapter
- Publication Details
- Precision Approaches to Heterogeneity in Asthma , pp.163-184
- Series
- Advances in experimental medicine and biology; v. 1426
- DOI
- 10.1007/978-3-031-32259-4_8
- PMID
- 37464121
- PMCID
- PMC13401788
- eISBN
- 3031322592; 9783031322594
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984445650702771
Metrics
17 Record Views