Book chapter
Impact of Chemotherapeutic Drugs Towards Oxidative Stress and Associated Multi-organ Physiological Responses
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, pp.3961-3985
Springer Nature Singapore
01/01/2022
DOI: 10.1007/978-981-16-5422-0_248
Abstract
Cancer represents a large burden on the global healthcare system, and many cancer chemotherapeutics are included on the World Health Organization’s list of essential medicines. However, the utility of these life-saving drugs is compromised by a series of dose-limiting adverse effects targeting multiple organ systems in the body. Indeed, the cytotoxic nature of these medications, required to kill cancer cells, often also impacts the viability of nonmalignant cell types. While many of these adverse events are rare and non-life-threatening, some are all too frequent, associated with debilitating symptoms, and have proven to contribute to increased morbidity and mortality in patients even following complete cancer remission. In this chapter, we focus on four main organ systems known to be damaged following cancer chemotherapy: the cardiovascular system, liver, kidneys, and peripheral nervous system. We highlight incidences, symptoms, and long-term complications of chemotherapy-induced cardiotoxicity, nephrotoxicity, hepatotoxicity, and neurotoxicity, which often depend on the unique pharmacokinetic and pharmacodynamic properties of individual drugs. For each system, we go on to describe particularly problematic agents, what is known from both the clinical and preclinical literature regarding the mechanism(s) underlying off-target cytotoxicity, and therapies that have proven efficacious in mitigating these adverse events. Agents discussed include anthracyclines, antibody-based agents, platinum-based drugs, antimetabolites, alkaloids, tyrosine kinase inhibitors, and antiestrogenic compounds. For many cancer patients, physicians must carefully balance the risk for long-term health complications with the need for life-saving therapies. Thus, ongoing efforts in the field seek to investigate the acute and chronic side effects associated with cancer chemotherapeutics with the ultimate goal of developing more efficacious and/or selective drugs or identifying useful adjuvants to ameliorate or prevent adverse effects associated with currently marketed pharmaceuticals.
Details
- Title: Subtitle
- Impact of Chemotherapeutic Drugs Towards Oxidative Stress and Associated Multi-organ Physiological Responses
- Creators
- Sreemoyee Chakraborti - Sanjay Gandhi Post Graduate Institute of Medical SciencesAdele Stewart - Florida Atlantic UniversityBiswanath Maity - Sanjay Gandhi Post Graduate Institute of Medical SciencesMaria WalczakTapati ChakrabortiPulak KarSomasri DamKuntal DeyMuthusamy Kunnimalaiyaan
- Resource Type
- Book chapter
- Publication Details
- Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, pp.3961-3985
- Publisher
- Springer Nature Singapore; Singapore
- DOI
- 10.1007/978-981-16-5422-0_248
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Neuroscience and Pharmacology; Iowa Neuroscience Institute
- Record Identifier
- 9984618526002771
Metrics
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