Book chapter
In Vitro Dissolution of Pharmaceutical Solids
Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications, pp.31-46
Wiley series in drug discovery and development, John Wiley & Sons, Inc.
2024
DOI: 10.1002/9781119660699.ch3
Abstract
In pharmaceutical solids, dissolution of the active pharmaceutical ingredient is a critical rate‐limiting step to its absorption and is often preceded by disintegration of the solid dosage form. The oral bioavailability of a drug invariably depends on its dissolution upon ingestion, absorption in the small intestine, and finally transport to its target site of action. The purpose of in vitro dissolution testing is to predict how a dosage form will perform in vivo . Immediate release dosage forms have different rate‐determining release mechanism compared to modified‐release dosage forms. Adherence to in vitro dissolution specifications can demonstrate batch‐to‐batch consistency of a manufactured product and provide a form of quality assurance for its oral bioavailability. Drug discovery pipelines in pharmaceutical research and development have been increasingly filled with poorly soluble compounds, with about 90% of the drugs in development being characterized as poorly soluble.
Details
- Title: Subtitle
- In Vitro Dissolution of Pharmaceutical Solids
- Creators
- Tze Ning Hiew - University of IowaPaul W.S Heng - National University of Singapore
- Resource Type
- Book chapter
- Publication Details
- Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications, pp.31-46
- Publisher
- John Wiley & Sons, Inc.; Hoboken, New Jersey
- Series
- Wiley series in drug discovery and development
- DOI
- 10.1002/9781119660699.ch3
- Language
- English
- Date published
- 2024
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984557945002771
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