Book chapter
In silico methods to model dose deposition
Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches, pp.167-195
Elsevier
01/01/2021
DOI: 10.1016/b978-0-12-814974-4.00012-2
Abstract
Abstract In this chapter, we review the current state of in silico tools for lung deposition applications and discuss how knowledge gathered from recent studies can be purposefully leveraged to design efficient hybrid multiscale lung models. We firstly address the different roles of in silico methods when applied to the human lung airways. We then discuss the variability of airflow and particle transport regimes in different regions of the human lung and how in silico methods are employed in each case. In the next section, we focus on numerical aspects associated with the application of computational fluid particle dynamics (CFPD) in the extrathoracic and upper conducting airways. We highlight the variability in airflow and deposition predictions in the upper airways across different CFPD methods and the necessity for validation and verification of computational tools. A review of models applied to the pulmonary acinus follows, in which we highlight how CFPD methods can deliver high-resolution spatiotemporal predictions of local acinar aerosol deposition. Towards integrated simulations covering the whole lung, we describe efforts to integrate 3D CFPD for the upper airways with models of the peripheral lung and discuss open issues and expected developments. We then discuss how CFPD can account for the non-standard lung, namely disease, age and gender effects. We close with a brief review of 1D models and how their predictions can be improved in the future by leveraging knowledge generated by the more complex 3D CFPD and hybrid approaches.
Details
- Title: Subtitle
- In silico methods to model dose deposition
- Creators
- Pantelis Koullapis - University of CyprusFotos Stylianou - University of CyprusChing-Long LinStavros C. Kassinos - University of CyprusJosué Sznitman - Technion – Israel Institute of Technology
- Resource Type
- Book chapter
- Publication Details
- Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches, pp.167-195
- Publisher
- Elsevier
- DOI
- 10.1016/b978-0-12-814974-4.00012-2
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering
- Record Identifier
- 9984573939902771
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