In vivo targeting function of N-linked oligosaccharides. Pharmacokinetic and biodistribution of N-linked oligosaccharides

Kevin G Rice; Ming H Chiu; Manpreet S Wadhwa; V.  Hayden Thomas; Hilary J Stubbs

doi:10.1007/978-1-4615-1885-3_30

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In vivo targeting function of N-linked oligosaccharides. Pharmacokinetic and biodistribution of N-linked oligosaccharides

Book chapter

Peer reviewed

In vivo targeting function of N-linked oligosaccharides. Pharmacokinetic and biodistribution of N-linked oligosaccharides

Kevin G Rice, Ming H Chiu, Manpreet S Wadhwa, V. Hayden Thomas and Hilary J Stubbs

Glycoimmunology, Vol.376, pp.271-282

Advances in experimental medicine and biology, 376, Springer

1995

DOI: 10.1007/978-1-4615-1885-3_30

PMID: 8597259

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Abstract

In plants and animals carbohydrate/protein interactions are fundamental to biological function. This form of biomolecular recognition usually involves binding of a carbohydrate ligand to a lectin receptor [1]. One of the well known and thoroughly studied lectin systems in mammals is the asialoglycoprotein receptor (ASGP-R) found on hepatocytes [2–5]. This receptor binds ligands with terminal galactose or N-acetylgalactosamine and routes these to lysosomes before recycling to the cell surface [6]. The natural ligands for the ASGP-R are believed to be serum glycoproteins which lose their terminal sialic acid during circulation exposing clusters of subterminal galactose residues on their N-linked oligosaccharides. Thereby, the ASGP-R is believed to be primarily involved in maintaining the serum concentration of structurally diverse glycoproteins.

Carbohydrate Sequence

Oligosaccharides - pharmacokinetics

Oligosaccharides - chemistry

Molecular Sequence Data

Acetylglucosamine

Glycosylation

Oligosaccharides - metabolism

Carbohydrate Conformation

Galactose

Tyrosine - analogs & derivatives

Fucose

Details

Title: Subtitle: In vivo targeting function of N-linked oligosaccharides. Pharmacokinetic and biodistribution of N-linked oligosaccharides
Creators: Kevin G Rice - Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State University, Columbus 43210, USA
Ming H Chiu
Manpreet S Wadhwa
V. Hayden Thomas
Hilary J Stubbs
Resource Type: Book chapter
Publication Details: Glycoimmunology, Vol.376, pp.271-282
Series: Advances in experimental medicine and biology; 376
DOI: 10.1007/978-1-4615-1885-3_30
PMID: 8597259
NLM abbreviation: Adv Exp Med Biol
ISSN: 0065-2598
Publisher: Springer; Boston, MA
Grant note: DK45742 / NIDDK NIH HHS GM48048 / NIGMS NIH HHS
Language: English
Date published: 1995
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
Record Identifier: 9984065697702771

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