Book chapter
Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths
he hygiene hypothesis and Darwinian medicine, pp.149-178
Progress in Inflammation Research Series, Walter De Gruyter
01/01/2009
Abstract
Variations in more than 40 genetic loci can alter the risk for developing inflammatory bowel disease (IBD). However, the epidemiology of ulcerative colitis and Crohn's disease suggest that a recent environmental change accounts for most of the disease risk. In this chapter we will introduce IBD and outline its dramatic rise in prevalence over the last 70 years. We will consider the effective eradication of helminths during this time period and the effects of helminths on immunity. We will review the current evidence that helminths induce regulatory immune circuits that suppress aberrant inflammation and may be useful clinically to treat immune-mediated disease.
Details
- Title: Subtitle
- Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths
- Creators
- David E. Elliott - Univ Iowa, Dept Internal Med, Div Gastroenterol & Hepatol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USAJoel V. Weinstock - College Station Medical Center
- Contributors
- GAW Rook (Editor)
- Resource Type
- Book chapter
- Publication Details
- he hygiene hypothesis and Darwinian medicine, pp.149-178
- Publisher
- Walter De Gruyter; BASEL
- Series
- Progress in Inflammation Research Series
- ISSN
- 1422-7746
- Number of pages
- 30
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984362352502771
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