Book chapter
Introduction: Nature's gift to neuroscience
Nature's Gift to Neuroscience, pp.1-1
CRC Press
2022
DOI: 10.1201/9781003239758-1
Abstract
In 1963, Sydney Brenner wrote a proposal to Max Perutz on tackling the next ‘big questions’ in molecular biology. Beginning with the postulate that simple organisms have many of the features that control development and physiology in more complex organisms, Brenner proposed ‘to tame a small metazoan’ to discover the ‘control mechanisms’ of development. Boldly, he proposed to identify and trace the lineage of every cell in a nematode worm. He was joined in this goal by John Sulston, who painstakingly produced the worm C. elegans cell lineages from single cell to adult. The product of this work, which was completed in the storied halls of the Medical Research Council’s Laboratory of Molecular Biology (MRC LMB), was transformative at the time and remains a valuable resource to this day. Among the many contributions of the lineage project, it led to the discovery of mechanisms of apoptosis with H. Robert Horvitz. For their work, Brenner, Sulston, and Horvitz shared the 2002 Nobel Prize in Physiology or Medicine.
Details
- Title: Subtitle
- Introduction: Nature's gift to neuroscience
- Creators
- Joy AlcedoYishi JinDouglas S. PortmanVeena PrahladDavid RaizenGeorgia RaptiX.Z. Shawn XuYun ZhangChun-Fang Wu
- Contributors
- Chun-Fang Wu (Editor)Joy Alcedo (Editor)
- Resource Type
- Book chapter
- Publication Details
- Nature's Gift to Neuroscience, pp.1-1
- Publisher
- CRC Press; Boca Raton
- DOI
- 10.1201/9781003239758-1
- Language
- English
- Date published
- 2022
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984554851502771
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