Book chapter
Juvenile Polyposis Syndrome
Intestinal Polyposis Syndromes, pp.69-86
Springer International Publishing
03/08/2016
DOI: 10.1007/978-3-319-28103-2_6
Abstract
Juvenile Polyposis is a hamartomatous polyposis syndrome with an autosomal dominant inheritance pattern. Patients commonly present with anemia or rectal bleeding in the first two decades of life. These polyps may range from a few to over a 100 in number, and most often are located within the colon or rectum, but may also be found in the stomach and occasionally in the small intestine. Germline mutations in BMPR1A or SMAD4 are responsible for approximately one-half of cases, and the predisposing gene for the other half is unknown. The diagnosis of JP carries with it an increased risk of GI malignancy, particularly of the colon, rectum, and stomach. Screening with colonoscopy and upper endoscopy begins when symptoms develop or at age 15, and colon polyps should be removed endoscopically when possible. Surgical treatment is reserved for those with large numbers of polyps, polyps with dysplasia or cancer, significant anemia, or extensive gastric involvement.
Details
- Title: Subtitle
- Juvenile Polyposis Syndrome
- Creators
- Kendall Keck - University of Iowa Carver College of Medicine, Iowa City, USAJames R. Howe - University of Iowa Hospitals and Clinics
- Resource Type
- Book chapter
- Publication Details
- Intestinal Polyposis Syndromes, pp.69-86
- Publisher
- Springer International Publishing; Cham
- DOI
- 10.1007/978-3-319-28103-2_6
- Language
- English
- Date published
- 03/08/2016
- Academic Unit
- Surgery
- Record Identifier
- 9984322946102771
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