Book chapter
Lessons Learned from CGRP Mutant Mice
Neurobiological Basis of Migraine, pp.175-188
John Wiley & Sons, Inc
07/12/2017
DOI: 10.1002/9781118967225.ch10
Abstract
Calcitonin gene‐related peptide (CGRP) plays a pivotal role in migraine pathogenesis, and the development of CGRP‐mutant mouse models has been fruitful in the ongoing delineation of the role of CGRP in migraine. This chapter reviews the current mouse models with altered CGRP signaling, and the lessons learned from each of these models. Modeling migraine in a mouse poses unique challenges, we cannot know for sure that a mouse has a headache. CGRP mutant mice also tend to show a lack of compensation to vascular challenges in the absence of CGRP activity, which is mirrored by increased resilience to some of those same challenges when the receptor is overexpressed. Serum CGRP levels are elevated during migraine, and this increase can be reversed with sumatriptan. The chapter also discusses the current state of migraine research, using mouse models that affect CGRP signaling.
Details
- Title: Subtitle
- Lessons Learned from CGRP Mutant Mice
- Creators
- Levi P SowersAnnie E TyeAndrew F Russo
- Contributors
- Turgay Dalkara (Editor)Michael A Moskowitz (Editor)
- Resource Type
- Book chapter
- Publication Details
- Neurobiological Basis of Migraine, pp.175-188
- DOI
- 10.1002/9781118967225.ch10
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ, USA
- Number of pages
- 14
- Language
- English
- Date published
- 07/12/2017
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Neurology (Pediatrics)
- Record Identifier
- 9984072061602771
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