Book chapter
Longitudinal Functional Magnetic Resonance Imaging in Animal Models
Magnetic Resonance Neuroimaging, pp.281-302
Methods in Molecular Biology, Humana Press Inc
01/01/2011
DOI: 10.1007/978-1-61737-992-5_14
PMCID: PMC4748954
PMID: 21279608
Abstract
Functional magnetic resonance imaging (fMRI) has had an essential role in furthering our understanding of brain physiology and function. fMRI techniques are nowadays widely applied in neuroscience research, as well as in translational and clinical studies. The use of animal models in fMRI studies has been fundamental in helping elucidate the mechanisms of cerebral blood-flow regulation, and in the exploration of basic neuroscience questions, such as the mechanisms of perception, behavior, and cognition. Because animals are inherently non-compliant, most fMRI performed to date have required the use of anesthesia, which interferes with brain function and compromises interpretability and applicability of results to our understanding of human brain function. An alternative approach that eliminates the need for anesthesia involves training the animal to tolerate physical restraint during the data acquisition. In the present chapter, we review these two different approaches to obtaining fMRI data from animal models, with a specific focus on the acquisition of longitudinal data from the same subjects.
Details
- Title: Subtitle
- Longitudinal Functional Magnetic Resonance Imaging in Animal Models
- Creators
- Afonso C. Silva - National Institute of Neurological Disorders and StrokeJunjie V. Liu - National Institute of Neurological Disorders and StrokeYoshiyuki Hirano - National Institute of Neurological Disorders and StrokeRenata F. Leoni - National Institute of Neurological Disorders and StrokeHellmut Merkle - National Institute of Neurological Disorders and StrokeJulie B. Mackel - National Institute of Neurological Disorders and StrokeXian Feng Zhang - National Institute of Neurological Disorders and StrokeGeorge C. Nascimento - Federal University of Rio Grande do NorteBojana Stefanovic - Sunnybrook Health Science Centre
- Contributors
- M Modo (Editor)JWM Bulte (Editor)
- Resource Type
- Book chapter
- Publication Details
- Magnetic Resonance Neuroimaging, pp.281-302
- Series
- Methods in Molecular Biology
- DOI
- 10.1007/978-1-61737-992-5_14
- PMID
- 21279608
- PMCID
- PMC4748954
- NLM abbreviation
- Methods Mol Biol
- eISSN
- 1940-6029
- ISSN
- 1064-3745
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 22
- Grant note
- ZIA NS003041-05; ZIA NS003012-05 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ZIANS003041 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Neurology
- Record Identifier
- 9984302207602771
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