Book chapter
Magnetic Resonance Imaging in Multiple Sclerosis
Multiple Sclerosis, pp.136-162
Wiley‐Blackwell
2012
DOI: 10.1002/9781119963714.ch6
Abstract
Magnetic resonance imaging (MRI) of the brain and spinal cord has become a routine tool for the diagnosis and monitoring of multiple sclerosis (MS) and has emerged as a key supportive outcome measure in clinical trials. Conventional MRI lesion and atrophy measures are particularly useful for assessing macroscopic damage but lack sensitivity and specificity to the underlying MS pathology. They also show relatively weak relationships to clinical status such as predictive strength for clinical change. Advanced MR techniques, such as diffusion, magnetization transfer imaging, relaxometry, and MR spectroscopy are relatively more specific and sensitive to the underlying pathology. These measures have provided unique insights into the pathophysiology of MS and may help resolve the dissociation between clinical and conventional MRI findings. This chapter summarizes the importance and role of MRI in the characterization of MS‐related brain and spinal cord tissue damage.
Details
- Title: Subtitle
- Magnetic Resonance Imaging in Multiple Sclerosis
- Creators
- Mohit Neema - Harvard UniversityAntonia Ceccarelli - Harvard Medical SchoolJonathan S Jackson - Harvard Medical SchoolRohit Bakshi - Brigham and Women's Hospital
- Contributors
- Howard L Weiner (Editor) - Brigham and Women's HospitalJames M Stankiewicz (Editor) - Brigham and Women's Hospital
- Resource Type
- Book chapter
- Publication Details
- Multiple Sclerosis, pp.136-162
- Publisher
- Wiley‐Blackwell; Chichester, West Sussex
- DOI
- 10.1002/9781119963714.ch6
- Number of pages
- 27
- Language
- English
- Date published
- 2012
- Academic Unit
- Psychiatry
- Record Identifier
- 9984627329202771
Metrics
1 Record Views