Book chapter
Magnetic Resonance Imaging in Psychiatry
NMR: Principles and Applications to Biomedical Research, pp.586-600
Springer New York
1990
DOI: 10.1007/978-1-4612-3300-8_20
Abstract
The development of in vivo brain imaging during the past several decades has offered psychiatrists their first opportunity to observe directly both the structure and the metabolic and neurochemical function in the brains of patients suffering from major mental illnesses. Computerized tomography (CT), techniques for measuring regional cerebral blood flew (rCBF), and positron emission tomography (PET) have all documented, for example, that patients suffering from schizophrenia have a variety of cerebral abnormalities (Johnstone et al 1976; Weinberger et al 1979 a,b; Andreasen 1982; Ingvar et al 1974; Weinberger et al 1986; Gur et al 1985; Gur et al 1987; Buchsbaum et al 1982, 1987; Sedvall et al 1986; Early et al 1987; Wong et al 1986). The most commonly observed abnormalities include: 1) ventricular enlargement, 2) decreased cerebral perfusion in the frontal lobes and difficulty in increasing perfusion in response to cognitive challenge, 3) decreased glucose utilization in the frontal cortex and difficulty in activation, and 4) hypermetabolic activity in subcortical regions such as the basal ganglia.
Details
- Title: Subtitle
- Magnetic Resonance Imaging in Psychiatry
- Creators
- N. C AndreasenJ. C EhrhardtV. W SwayzeN. R BlakleyW. T. C Yuh
- Resource Type
- Book chapter
- Publication Details
- NMR: Principles and Applications to Biomedical Research, pp.586-600
- DOI
- 10.1007/978-1-4612-3300-8_20
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 1990
- Academic Unit
- Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984068245902771
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