Book chapter
Major Immediate-Early Enhancer and Its Gene Products
Cytomegaloviruses: From Molecular Pathogenesis to Intervention, pp.152-173
Caister Academic Press
01/01/2013
Abstract
CMV major immediate-early (MIE) gene expression activates the viral replicative cycle in both acute and reactivation infections and is greatly restricted in latent infection. Specific signalling cascades, transcriptional regulatory hierarchies, and cis-regulatory codes govern the initiation efficacy, magnitude, and sustainability of MIE gene transcription. The MIE enhancer/promoter, a major determinant in viral fitness, is at the heart of this control. It is equipped with complex regulatory circuitry that integrates diverse viral, cellular, and environmental cues. The MIE genes via differential RNA splicing produce a set of multifunctional proteins that function directly in advancing the viral life cycle. CMV-induced disease genesis is driven by the regulatory mechanisms underlying both the expression of the MIE genes and the actions of the MIE gene products. A better understanding of the MIE enhancer and its gene products could potentially spawn novel strategies for preventing CMV-related disease.
Details
- Title: Subtitle
- Major Immediate-Early Enhancer and Its Gene Products
- Creators
- Jeffery L. Meier - Univ Iowa Hosp & Clin, Dept Internal Med, Iowa City, IA 52242 USAMark F. Stinski - Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
- Contributors
- M J Reddehase (Editor)
- Resource Type
- Book chapter
- Publication Details
- Cytomegaloviruses: From Molecular Pathogenesis to Intervention, pp.152-173
- Publisher
- Caister Academic Press; WYMONDHAM
- Number of pages
- 22
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Microbiology and Immunology; Epidemiology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984363156402771
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