Book chapter
Manipulating redox active metal metabolism to enhance cancer therapy
Improving the Therapeutic Ratio in Head and Neck Cancer, pp.221-234
Cancer Sensitizing Agents for Chemotherapy, Elsevier
01/01/2020
DOI: 10.1016/B978-0-12-817868-3.00010-X
Abstract
Redox active metals, including iron, play essential roles in regulating cellular growth and metabolism. Approximately 2% of cellular iron is unbound and can participate in redox reactions. This labile iron pool (LIP) is tightly regulated by cells as excess LIP can participate in Fenton chemistry reactions generating reactive oxygen species. Many malignancies have increased iron uptake resulting in increased LIPs that contribute to cancer proliferation. Iron chelation therapy reduces LIPs and slows cancer progression. Alternatively, treatment with pharmacological ascorbate further increases cancer cell LIPs thereby increasing oxidative stress. Currently multiple clinical trials are combining pharmacological ascorbate with radiation and chemotherapy in a variety of cancers. Drugs containing redox active catalytic metals are also reducing radiation and chemotherapy-induced toxicity.
Details
- Title: Subtitle
- Manipulating redox active metal metabolism to enhance cancer therapy
- Creators
- M. S. Petronek - University of IowaB. G. Allen - University of Iowa
- Contributors
- R J Kimple (Editor)
- Resource Type
- Book chapter
- Publication Details
- Improving the Therapeutic Ratio in Head and Neck Cancer, pp.221-234
- Publisher
- Elsevier; LONDON
- Series
- Cancer Sensitizing Agents for Chemotherapy
- DOI
- 10.1016/B978-0-12-817868-3.00010-X
- eISSN
- 2468-3116
- ISSN
- 2468-3183
- Number of pages
- 14
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Radiation Oncology; Iowa Neuroscience Institute
- Record Identifier
- 9984446416502771
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