Book chapter
Mas and Neuroprotection in Stroke
The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications, pp.201-205
Elsevier/Academic Press
2015
DOI: 10.1016/B978-0-12-801364-9.00028-6
Abstract
In this chapter, we explore the beneficial actions in stroke elicited by the activation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/receptor Mas axis of the renin-angiotensin system. The neuroprotective efficacy in stroke of targeted manipulation of this axis is becoming well-established, thanks to findings from an increasing number of studies, which use a variety of stroke models and activating compounds. As part of a discussion of the effects of angiotensin-(1-7) in the brain and other tissues, we also describe several possible mechanisms by which the receptor Mas exerts its neuroprotective effects. Finally, we identify important steps to the clinical translation of these promising findings from the bench to the bedside.
Details
- Title: Subtitle
- Mas and Neuroprotection in Stroke
- Creators
- Douglas M. Bennion - University of FloridaRobert W. Regenhardt - University of FloridaAdam P. Mecca - University of FloridaColin Sumners - University of Florida
- Resource Type
- Book chapter
- Publication Details
- The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications, pp.201-205
- DOI
- 10.1016/B978-0-12-801364-9.00028-6
- Publisher
- Elsevier/Academic Press; Amsterdam
- Number of pages
- 5
- Language
- English
- Date published
- 2015
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984962626902771
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