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Maternal antibody-modulated MHV-JHM infection in C57BL/6 and BALB/c mice
Book chapter   Open access   Peer reviewed

Maternal antibody-modulated MHV-JHM infection in C57BL/6 and BALB/c mice

S Perlman, R Schelper and D Ries
Coronaviruses, Vol.218, pp.297-305
Advances in experimental medicine and biology, 218, Springer
1987
DOI: 10.1007/978-1-4684-1280-2_39
PMID: 2829543
url
https://doi.org/10.1007/978-1-4684-1280-2_39View
Published (Version of record) Open Access

Abstract

1. Maternal antibody protected C57BL/6 and BALB/c suckling mice from the acute, fatal encephalomyelitis caused by MHV-JHM. 2. 40% of the C57BL/6 mice and 25% of the BALB/c mice which were protected by maternal antibody developed neurological disease days to weeks later. Although the clinical syndromes developed by the two different strains were different, in both cases the mice developed a demyelinating encephalomyelitis with fewer inflammatory changes present in the grey matter. 3. Presence or absence of neutralizing antibody in the sera of maternal antibody-protected C57BL/6 mice did not correlate with the development of clinically evident neurological disease. 4. Infectious virus could only be isolated from C57BL/6 mice with neurological disease, although viral antigen could be detected in most mice whether symptomatic or not. 5. This model should be useful for the study of the viral and immune factors important in MHV-induced viral demyelination.
 Pregnancy Antibodies, Viral - biosynthesis Immunity, Maternally-Acquired Mice, Inbred C57BL Murine hepatitis virus - immunology Antigens, Viral - isolation & purification Animals Animals, Suckling Coronaviridae Infections - prevention & control Encephalomyelitis - prevention & control Female Demyelinating Diseases - etiology Mice Mice, Inbred BALB C

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