Book chapter
Mechanisms of Development
Clinical Neuroembryology: Development and Developmental Disorders of the Human Central Nervous System, pp.77-169
Springer International Publishing AG, Third edition
2023
Abstract
Many of the mechanisms underlying neural development are basically similar in vertebrates and invertebrates. Among vertebrates, popular species for experimental studies are zebrafish, the South African clawed toad, the chick embryo and mice. In mice, many spontaneously occurring mutations affecting the cerebral cortex and the cerebellum have been described. Their molecular analysis, combined with transgenic technology to achieve ectopic gene expression and targeted gene ablation, has made the mouse the mammal of choice for molecular genetic studies of early development.
In this chapter, mechanisms of development will be discussed with emphasis on neural induction (► Sect. 2.2), cell lineage studies and fate mapping (► Sect. 2.3), pattern formation of the forebrain and the hindbrain (► Sect. 2.4), specification of cell fate from the spinal cord to the telencephalon (► Sect. 2.5), neurogenesis, gliogenesis and migration, of the cerebral cortex in particular (► Sect. 2.6), axon outgrowth and guidance, focussing on the corpus callosum, the pyramidal tract, thalamocortical projections and the formation of topographic maps (► Sect. 2.7) and programmed cell death (► Sect. 2.8).
Details
- Title: Subtitle
- Mechanisms of Development
- Creators
- Hans J ten DonkelaarBernd Fritzsch
- Resource Type
- Book chapter
- Publication Details
- Clinical Neuroembryology: Development and Developmental Disorders of the Human Central Nervous System, pp.77-169
- Edition
- Third edition
- ISBN
- 303126097X; 9783031260971
- eISBN
- 9783031260988; 3031260988
- Publisher
- Springer International Publishing AG; Cham
- Number of pages
- 1 online resource (926 pages)
- Language
- English
- Date published
- 2023
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984464481002771
Metrics
39 Record Views