Book chapter
Mechanisms of pathogenesis of staphylococcal and streptococcal superantigens
Bacterial Infection: Close Encounters at the Host Pathogen Interface, pp.81-97
Current topics in microbiology and immunology, 225, Springer
1998
DOI: 10.1007/978-3-642-80451-9_5
PMID: 9386329
Abstract
In order to infect a host successfully, to access nutrients, and to promote the progression of disease, many pathogenic bacteria, such as the staphylococci and streptococci, produce exoproteins which enhance microbial virulence. Among these proteins is the family of toxins known today as the superantigens (SAg). This family includes the pyrogenic toxin SAg (PTSAg), such as the staphylococcal enterotoxins (SE, serotypes A-E, G, H), group A streptococcal pyrogenic exotoxins (SPE, serotypes A-C and possibly F), streptococcal SAg (SSA), and staphylococcal toxic shock syndrome toxin (TSST)-1. The following is a review of the biochemistry, structure, and mechanisms of pathogenicity of the PTSAg and the shared and unique properties of each. The properties of other relevant superantigenic proteins such as the staphylococcal exfoliative toxins (ETA, ETB) will also be discussed.
Details
- Title: Subtitle
- Mechanisms of pathogenesis of staphylococcal and streptococcal superantigens
- Creators
- J V Rago - University of Minnesota Medical School, Department of Microbiology, Minneapolis 55455-0312, USAP M Schlievert
- Resource Type
- Book chapter
- Publication Details
- Bacterial Infection: Close Encounters at the Host Pathogen Interface, pp.81-97
- Publisher
- Springer; Berlin
- Series
- Current topics in microbiology and immunology; 225
- DOI
- 10.1007/978-3-642-80451-9_5
- PMID
- 9386329
- ISSN
- 0070-217X
- Grant note
- HL36611 / NHLBI NIH HHS AI22159 / NIAID NIH HHS
- Language
- English
- Date published
- 1998
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001113502771
Metrics
21 Record Views