Book chapter
Meningioma
Adult CNS Radiation Oncology, pp.3-24
Springer Nature Switzerland, Second edition
2024
DOI: 10.1007/978-3-031-67878-3_1
Abstract
Meningiomas are the most prevalent primary intracranial neoplasm. To date, the main management options are observation, surgical resection, and radiation therapy. Decisions regarding optimal management depend largely upon symptoms, size, anatomic localization, growth rate, extent of resection, tumor grade, edema, and prior treatment, recognizing that advances in molecular profiling are well underway. Although meningiomas are typically benign, grade 2 lesions carry a higher risk of recurrence and morbidity. Grade 3 meningiomas are frankly malignant, fortunately rare (1–3% of meningiomas), and carry even higher risks. The role of radiation therapy had been based largely on retrospective studies, but four contemporary prospective cooperative group trials (EORTC 22042-26042, RTOG 0539, NRG BN003, and ROAM/EORTC 1308) are further defining its use. Recent advances in genomics have revealed novel aberrations in meningiomas at both genetic and epigenetic levels and are shedding light on individualized risk stratification and therapeutics. The role of systemic therapy is limited, but studies are ongoing and necessary. This chapter will review its epidemiology, histology, grade, genomics, treatment, and studies, based on both historical and recent literature.
Details
- Title: Subtitle
- Meningioma
- Creators
- Kailin Yang - University of IowaTimothy J. Harris - Virginia Commonwealth UniversitySamuel T. Chao - Cleveland ClinicC. Leland Rogers - Utah Cancer Specialists
- Contributors
- Eric L. Chang (Editor)Paul D. Brown (Editor)Simon S. Lo (Editor)Arjun Sahgal (Editor)John H. Suh (Editor)
- Resource Type
- Book chapter
- Publication Details
- Adult CNS Radiation Oncology, pp.3-24
- Edition
- Second edition
- Publisher
- Springer Nature Switzerland; Cham
- DOI
- 10.1007/978-3-031-67878-3_1
- Language
- English
- Date published
- 2024
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984756242002771
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